Synthesis, spectral characterization and DNA/Protein binding studies on Cobalt (II) complex containing Mixed ligand Ethylenediamine with 2-Hydroxy-1-Naphthaldehyde

Kadhiravan S, Sivajiganesan S, Periyathambi T, Nanthakumar V

Abstract


New cobalt (II) complex has been synthesized and characterized by elemental analysis, UV-Vis, FT-IR and thermal analysis. Binding of this Co (II) complex with calf thymus DNA was investigated by UV-Visible absorption, fluorescence spectroscopy techniques. The intrinsic binding constants Kb of complex with CT-DNA obtained from UV-Vis absorption studies were 4.43 × 105M-1. Further, the in vitro cytotoxic effect of the complexes examined on cancerous cell line, such as human breast cancer cells (MCF-7). 


Keywords


Co (II) complex, DNA interaction and cytotoxicity activity

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Copyright (c) 2017 Kadhiravan S, Sivajiganesan S, Periyathambi T, Nanthakumar V

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