Synthesis, Characterization, and Biological Evaluation of Some 3d-Metal Complexes of Schiff Base Derived from Sulfonamide Drug

Abstract

A sulfonamide based novel acyclic bidentate compartmental ligand E-4-(((1H-indol-3-yl)methylene)amino)-N-(pyridine-2-yl) benzenesulfonamide was prepared by condensation of Indole-3-carbaldehyde with sulphapyridine in equimolar ratio in ethanol. The reaction of metal chlorides (Mn(II), Co(II), and Cu(II) with the newly synthesised ligand in methanol results the formation of deep colored metal complexes with the formula [ML₂]Cl₂ (M=Mn, Co, and Cu). The free ligand and its metal complexes were characterized by elemental analyses, conductometric measurements, IR, UV-Vis,¹H and ¹³CNMR and EI Mass spectrometric techniques. The physical measurements and FTIR spectral data showed that most of the complexes contain octahedrally coordinated to the central ion (II). The antibacterial activity of the ligand and its complexes was done by well diffusion method using DMSO as inert solvent and the test solution was diffused into the plate and affected the growth of the incubated microorganisms such as staphylococcus aureus, E.coli, Bacillus, Aspergillus niger. The values of zone ofinhibition were found out at 37 ºC for a period of 24 h. It has beenfound that all the complexes have higher activity than the free ligandand the standard.