@article{Baskaran Subramani_Baradwaj R.G_2016, title={Antibacterial, anti-oxidant and in vitro anticancer analysis of Zingiber officinale (L.) Rosc.}, volume={1}, url={http://mail.joaasr.com/index.php/joaasr/article/view/35}, DOI={10.46947/joaasr16201635}, abstractNote={<p>Ginger is considered as an important spice with many clinical potential activities. The present study was undertaken to determine antimicrobial, antioxidant and <em>in vitro</em> anticancer activities of rhizome extract of <em>Zingiber officinale</em>. Antimicrobial activity was tested against <em>Staphylococcus aureus, Bacillus subtilis, Vibrio cholera, Vibrio parahaemolyticus, Pseudomonas aeruginosa, Entero toxigenic Excherichia coli </em>(ETEC) <em>and Salmonella typhi </em>by disc diffusion assay. Antioxidant activity was determined by DPPH free radical scavenging assay and ABTS free radical scavenging assay. The ethanolic extract showed more activity against <em>Vibrio cholera, Vibrio parahaemolyticus, </em>ETEC and <em>Salmonella typhi</em>  at 5–25 mg/well.  The extract also exhibited dose dependent scavenging of DPPH and ABTS radicals. Scavenging of DPPH radicals was more efficient than that of ABTS radicals as revealed by the low IC<sub>50</sub> value. MCF-7 breast cancer cells were used to investigate the <em>in vitro </em>anticancer activity of ethanol extracts of ginger. The inhibitory activity of the extracts against MCF-7 was carried out using colorimetric tetrazolium salt (MTT) assay<strong>. </strong>The results showed considerable anticancer activity in MCF–7 cancer cells, with an IC<sub>50</sub> value of 10 µg/ml. Ginger extract effectively inhibited proliferation of MCF-7 cells in a dose-dependent manner over 24h. Thus the compounds of ginger displaied potential for antioxidant, antibacterial and anticancer agents. </p>}, number={6}, journal={JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH}, author={Baskaran Subramani and Baradwaj R.G}, year={2016}, month={Dec.}, pages={33–49} }